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In scientific studies of other receptor tyrosine kinases implicated during the oncogenesis of GIST, nilotinib realized strong and selective inhibition of PDGFR? and PDGFR?. As is the case with imatinib, nilotinib potently inhibited the autophosphorylation of A31 cells transformed by PDGFRAnilotinib will increase the degree or effect of disopyramide

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